Thermodynamic parameters for DNA sequences with dangling ends

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Thermodynamic parameters for DNA sequences with dangling ends.

The thermodynamic contributions to duplex formation of all 32 possible single-nucleotide dangling ends on a Watson-Crick pair are reported. In most instances, dangling ends are stabilizing with free energy contributions ranging from +0.48 (GT(A)) to-0.96 kcal/mol (). In comparison, Watson-Crick nearest-neighbor increments range from -0. 58 (TA/AT) to -2.24 (GC/CG) kcal/mol. Hence, in some cases...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2000

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/28.9.1929